Double Asynchronous Switching Control for Takagi–Sugeno Fuzzy Markov Jump Systems via Adaptive Event-Triggered Mechanism

This article addresses the issue of adaptive event- triggered H∞ control for Markov jump systems based on Takagi-Sugeno (T-S) fuzzy model. Firstly, a new double asynchronous switching controller is presented to deal with the problem of the mismatch of premise variables and modes between the controller and the plant, which is widespread in real network environment. To further reduce the power consumption of communication, a switching adaptive event-triggered mechanism is adopted to relieve the network transmission pressure while ensuring the control effect. In addition, a new Lyapunov-Krasovskii functional (LKF) is constructed to reduce conservatism by introducing the membership functions (MFs) and time-varying delays informa- tion. Meanwhile, the invariant set is estimated to ensure the stability of the system. And the disturbance rejection ability is measured by the optimal H∞ performance index. Finally, two examples are presented to demonstrate the effectiveness of the proposed approach

Asynchronous switching control for fuzzy Markov jump systems with periodically varying delay and its application to electronic circuits

This article focuses on addressing the issue of asynchronous H∞ control for Takagi-Sugeno (T-S) fuzzy Markov jump systems with generally incomplete transition probabilities (TPs). The delay is assumed to vary periodically, resulting in one monotonically increasing interval and one monotonically decreasing interval during each period. Meanwhile, a new Lyapunov-Krasovskii functional (LKF) is devised, which depends on membership functions (MFs) and two looped functions formulated for the monotonic intervals. Since the modes and TPs of the original system are assumed to be unavailable, an asynchronous switching fuzzy controller on the basis of hidden Markov model is proposed to stabilize the fuzzy Markov jump systems (FMJSs) with generally incomplete TPs. Consequently, a stability criterion with improved practicality and reduced conservatism is derived, ensuring the stochastic stability and H∞ performance of the closed-loop system. Finally, this technique is employed to the tunnel diode circuit system, and a comparison example is given, which verifies the practicality and superiority of the method

Proteomic analysis of rat serum revealed the effects of chronic sleep deprivation on metabolic, cardiovascular and nervous system

Sleep is an essential and fundamental physiological process that plays crucial roles in the balance of psychological and physical health. Sleep disorder may lead to adverse health outcomes. The effects of sleep deprivation were extensively studied, but its mechanism is still not fully understood. The present study aimed to identify the alterations of serum proteins associated with chronic sleep deprivation, and to seek for potential biomarkers of sleep disorder mediated diseases. A label-free quantitative proteomics technology was used to survey the global changes of serum proteins between normal rats and chronic sleep deprivation rats. A total of 309 proteins were detected in the serum samples and among them, 117 proteins showed more than 1.8-folds abundance alterations between the two groups. Functional enrichment and network analyses of the differential proteins revealed a close relationship between chronic sleep deprivation and several biological processes including energy metabolism, cardiovascular function and nervous function. And four proteins including pyruvate kinase M1, clusterin, kininogen1 and profilin-1were identified as potential biomarkers for chronic sleep deprivation. The four candidates were validated via parallel reaction monitoring (PRM) based targeted proteomics. In addition, protein expression alteration of the four proteins was confirmed in myocardium and brain of rat model. In summary, the comprehensive proteomic study revealed the biological impacts of chronic sleep deprivation and discovered several potential biomarkers. This study provides further insight into the pathological and molecular mechanisms underlying sleep disorders at protein level

Ambient volatile organic compounds in a suburban site between Beijing and Tianjin : Concentration levels, source apportionment and health risk assessment

Volatile organic compounds (VOCs) have vital implications for secondary pollutants, atmospheric oxidation and human health. Ambient VOCs were investigated using an online system, gas chromatography-mass spectrometry/flame ionization detector (GC-MS/FID), at a suburban site in Xianghe in the North China Plain from 6 November 2017 to 29 January 2018. Positive matrix factorization (PMF) receptor model was applied to identify the major VOC contributing sources. Four-step health risk assessment method was used to estimate risks of all risk-posing VOC species. A total of 101 VOCs were quantified, and the mean concentration of total VOCs was 61.04 +/- 65.18 ppbv. The VOCs were dominated by alkanes (38.76%), followed by alkenes, aromatics, halocarbons, OVOCs, acetylene and acetonitrile. The results of PMF revealed that vehicle exhaust, industrial emissions, liquefied petroleum gas & natural gas, solvent utilization and secondary and long-lived species contributed 31.0%, 26.4%, 18.6%, 13.6% and 10.4%, respectively, to the total VOCs. Pollutant-specific and source-specific non-carcinogenic and carcinogenic risk estimates were conducted, which showed that acrolein and vehicle exhaust had evident noncarcinogenic risks of 4.9 and 0.9, respectively. The carcinogenic risks of specific species (1,3-butadiene, acetaldehyde, benzene, chloroformand 1,2-dichloroethane) and identified sources were above the United States Environmental Protection Agency (USEPA) acceptable level (1.0 x 10(-6)) but below the tolerable risk level (1.0 x 10(-4)). Vehicle exhaust was the largest contributor (56.2%) to noncarcinogenic risk, but solvent utilization (32.6%) to carcinogenic risk. Moreover, with the evolution of pollution levels, almost all VOC species, contributions of alkenes, aromatics, solvent utilization and vehicle exhaust, and pollutant-specific and source-specific risks increased continuously and noticeably. Collectively, our findings unraveled the importance of alkenes, aromatics, solvent utilization and vehicle exhaust in the evolution of pollution levels. Future studies should consider targeting these VOC groups and sources when focusing on effective reduction strategies and assessing public health risks. (c) 2019 Elsevier B.V. All rights reserved.Peer reviewe

Ethanol’s Effect on Coq7 Expression in the Hippocampus of Mice

Coenzyme Q (CoQ) is a well-studied molecule, present in every cell membrane in the body, best known for its roles as a mitochondrial electron transporter and a potent membrane anti-oxidant. Much of the previous work was done in vitro in yeast and more recent work has suggested that CoQ may have additional roles prompting calls for a re-assessment of its role using in vivo systems in mammals. Here we investigated the putative role of Coenzyme Q in ethanol-induced effects in vivo using BXD RI mice. We examined hippocampal expression of Coq7 in saline controls and after an acute ethanol treatment, noting enriched biologic processes and pathways following ethanol administration. We also identified 45 ethanol-related phenotypes that were significantly correlated with Coq7 expression, including six phenotypes related to conditioned taste aversion and ethanol preference. This analysis highlights the need for further investigation of Coq7 and related genes in vivo as well as previously unrecognized roles that it may play in the hippocampus